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DD genotype of angiotensin‐converting enzyme in type 2 diabetes mellitus with renal disease in Mexican Mestizos
Author(s) -
PALOMOPIÑÓN SILVIA,
GUTIÉRREZRODRÍGUEZ MARGARITA E,
DÍAZFLORES MARGARITA,
SÁNCHEZBARRERA REYNA,
VALLADARESSALGADO ADÁN,
UTRERABARILLAS DOLORES,
DURÁNREYES GENOVEVA,
GALVÁNDUARTE ROSA E,
TRINIDADRAMOS PEDRO,
CRUZ MIGUEL
Publication year - 2009
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2008.01034.x
Subject(s) - albuminuria , medicine , genotype , diabetic nephropathy , diabetes mellitus , angiotensin converting enzyme , type 2 diabetes mellitus , endocrinology , nephropathy , type 1 diabetes , kidney disease , polymorphism (computer science) , gastroenterology , genetics , biology , blood pressure , gene
SUMMARY Aim: The DD genotype of angiotensin‐converting enzyme (ACE) has been suggested as a major contributor of diabetic nephropathy in several populations. The purpose of the present study was to determine whether micro/macroalbuminuria is associated with ACE insertion/deletion (I/D) polymorphism in Mexican Mestizos with type 2 diabetes mellitus. Methods: A total of 435 patients with type 2 diabetes mellitus, of whom 233 had albuminuria, were characterized for the ACE I/D polymorphism by the polymerase chain reaction method. Results: Clinical and biochemical characteristics and frequencies according to DD, ID and II genotypes in patients with and without albuminuria showed no significant differences. However, only females with micro/macroalbuminuria showed higher frequency of a DD genotype than those without albuminuria (27.9%, 21.2% and 10.5%, respectively; P ≤ 0.044). In addition, female patients with macroalbuminuria without dialysis showed no significant differences with patients undergoing dialysis. Conclusion: The ACE DD genotype is a risk factor for the development of renal disease in Mexican Mestizo females with type 2 diabetes, indicating a possible DD genotype‐associated sex effect in renal disease.