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Murine renal ischaemia‐reperfusion injury (Methods in Renal Research Paper)
Author(s) -
KENNEDY SEAN E,
ERLICH JONATHAN H
Publication year - 2008
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2008.00979.x
Subject(s) - medicine , ischemia , kidney , acute kidney injury , reperfusion injury , myocardial ischaemia , cardiology , intensive care medicine
SUMMARY: Ischaemia/reperfusion is a major cause of acute kidney injury in native and transplant kidneys and is associated with significant morbidity and mortality. Murine models of renal ischaemia/reperfusion injury have great potential to improve understanding of the underlying processes and are an important focus of ongoing research into therapeutic and preventative strategies. Like all experimental models, murine models of renal ischaemia/reperfusion are prone to significant variability and results may be influenced by a number of technical and design factors. In this article we review the factors that may influence experimental results and provide a guide to conducting reproducible experiments in murine renal ischaemia/reperfusion.