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Current status of dosing and quantification of acute renal replacement therapy. Part 2: Dosing paradigms and clinical implementation (Review Article)
Author(s) -
MARSHALL MARK R
Publication year - 2006
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2006.00581.x
Subject(s) - medicine , dosing , renal replacement therapy , acute kidney injury , intensive care medicine , renal function , medical prescription , pharmacology
SUMMARY: The dosing and quantification of acute renal replacement therapy has emerged as one of the most pressing issues in the management of critically‐ill patients with acute kidney injury. Although there is ongoing debate as to the best marker of uraemic injury in this setting, several landmark studies have identified clearance‐related expressions of acute renal replacement therapy dose as important determinants of survival. Part 1 of this review examined the factors affecting the delivery of prescribed acute renal replacement therapy dose. Part 2 summarises and contextualises findings from recent dose‐outcome studies, and reviews clinical tools to assist in the prescription and quantification of acute renal replacement therapy dose.