Premium
Propylthiouracil attenuates acetaminophen‐induced renal damage in the rat
Author(s) -
ABRAHAM PREMILA,
KANAKASABAPATHY INDIRANI,
DIAN BONDU JOSEPH
Publication year - 2005
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2005.00494.x
Subject(s) - propylthiouracil , medicine , acetaminophen , nephrotoxicity , glutathione , endocrinology , kidney , centrilobular necrosis , creatinine , pharmacology , necrosis , thyroid , enzyme , biochemistry , chemistry
SUMMARY: Background: To date, there is no specific antidote to acetaminophen poisoning. Propylthiouracil (PTU) has been shown to be protective against acetaminophen (APAP)‐induced liver damage in rats; however, the nephroprotective effect of propylthiouracil has not been studied yet. Methods: In order to verify this, rats were given different doses of PTU (100, 200 or 400 mg/kg per body weight, orally) 1 h before a nephrotoxic dose of APAP (1000 mg/kg per body weight, intraperitoneally (i.p.)). Results: Propylthiouracil pretreatment significantly reduced APAP‐induced nephrotoxicity in a dose‐dependant manner, as evidenced by reduction in plasma creatinine and by amelioration of renal pathology (interstitial congestion, tubular cell degeneration and necrosis). Conclusion: The mechanism of protection by PTU is probably not due to the sparing effect of non‐protein thiol (approximately 95% of which is reduced glutathione), as similar depletion of renal glutathione was observed regardless of PTU pretreatment; other mechanisms are suggested.