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Cardiac troponin I and beta 2 microglobulin as risk factors for early‐onset atherosclerosis in patients on haemodialysis
Author(s) -
ZUMRUTDAL AYSEGUL,
SEZER SIREN,
DEMIRCAN SENOL,
SEYDAOGLU GULSAH,
OZDEMIR F NURHAN,
HABERAL MEHMET
Publication year - 2005
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2005.00475.x
Subject(s) - medicine , erythrocyte sedimentation rate , cardiology , fibrinogen , left ventricular hypertrophy , beta 2 microglobulin , body mass index , homocysteine , intima media thickness , endocrinology , blood pressure , carotid arteries
SUMMARY: Aim: To investigate the associations of different risk factors with carotid artery intima‐media thickness (C‐IMT) in non‐diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis. Methods: Seventy‐two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time on HD: 47.9 ± 40.0 months) and 40 age‐ and sex‐matched healthy controls (26 men, 14 women; mean age: 35.5 ± 7.1 years) participated in the study. The relationship between C‐IMT and haematocrit‐corrected erythrocyte sedimentation rate (Hct‐corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C‐reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined. Results: Mean C‐IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C‐IMT of patients was positively correlated with age ( r = 0.33), body mass index ( r = 0.40), Hct‐corrected ESR ( r = 0.37), CRP ( r = 0.34), beta2M ( r = 0.34), cTnI ( r = 0.26), triglyceride ( r = 0.26) and fibrinogen ( r = 0.28) levels ( P < 0.05 for all). The mean C‐IMT was significantly greater in patients with LVH than it was in those without LVH ( P = 0.004). In multivariate regression analysis, age ( P = 0.02), beta2M ( P = 0.001), log‐transformed CRP ( P = 0.03) and LVH ( P = 0.01) were independently related with C‐IMT. Conclusion: Besides well‐known cardiovascular (CV) risk factors, cTnI and beta2M were related with C‐IMT in that they may have important roles in early‐onset atherosclerosis in this high‐risk population.