Premium
Hypersensitivity reactions to the polysorbate contained in recombinant erythropoietin and darbepoietin (Case Report)
Author(s) -
STEELE RICHARD H,
LIMAYE SANDHYA,
CLELAND BRUCE,
CHOW JOSEPHINE,
SURANYI MICHAEL G
Publication year - 2005
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2005.00389.x
Subject(s) - medicine , pure red cell aplasia , excipient , erythropoietin , polysorbate , recombinant dna , incidence (geometry) , pharmacology , anemia , biochemistry , pulmonary surfactant , chemistry , gene , physics , optics
SUMMARY: The following case reports are of two patients who have developed hypersensitivity reactions to the red cell growth hormones, darbepoietin and erythropoietin. The subsequent skin testing and clinical course suggested that the cause of these reactions was due to the excipient polysorbate 80. This finding might have implications in the recent increase in the incidence of pure red cell aplasia.