Premium
Caveolins in the repair phase of acute renal failure after oxidative stress
Author(s) -
PERCY CHRISTINE,
WATERS MICHAEL J,
GOBÉ GLENDA
Publication year - 2004
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2004.00356.x
Subject(s) - caveolae , oxidative stress , medicine , pathophysiology , microbiology and biotechnology , oxidative phosphorylation , kidney , caveolin , programmed cell death , ischemia , acute kidney injury , signal transduction , apoptosis , biochemistry , biology
SUMMARY: Ischaemia‐reperfusion and toxic injury are leading causes of acute renal failure (ARF). Both of these injury initiators use secondary mediators of damage in oxygen‐derived free radicals. Several recent publications about ischaemia‐reperfusion and toxin‐induced ARF have indicated that plasma membrane structures called caveolae, and their proteins, the caveolins, are potential participants in protecting or repairing renal tissues. Caveolae and caveolins have previously been ascribed many functions, a number of which may mediate cell death or survival of injured renal cells. This review proposes possible pathophysiological mechanisms by which altered caveolin‐1 expression and localization may affect renal cell survival following oxidative stress.