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Low protein diet causes a decrease in serum concentrations of leptin and tumour necrosis factor‐alpha in patients with conservatively treated chronic renal failure
Author(s) -
KOZŁOWSKA LUCYNA,
ROSOŁOWSKAHUSZCZ DANUTA,
RYDZEWSKI ANDRZEJ
Publication year - 2004
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2004.00327.x
Subject(s) - medicine , leptin , chronic renal failure , alpha (finance) , tumor necrosis factor alpha , endocrinology , necrosis , surgery , obesity , construct validity , patient satisfaction
SUMMARY: Background: Chronic renal failure (CRF) provokes derangement in various hormonal regulations of food intake and energy expenditure. In the present study, we have examined the effect of a low protein, low phosphorus diet on circulating levels of leptin, tumour necrosis factor (TNF)‐alpha, and insulin in patients with CRF. Methods: Seventeen male, non‐diabetic subjects with conservatively treated CRF (estimated creatinine clearance 39.5 ± 11.1 mL/min), and proteinuria below 2 g/day were prospectively studied. Measurements of hormonal, metabolic and anthropometric parameters were performed before and after 16 weeks of dietary treatment (protein 0.6 g/kg of ideal body mass, 30% of calories derived from fat, 62% of calories derived from carbohydrates and 10 mg/kg of phosphorus). Actual dietary intake in patients was measured by using 3‐day food records and was supervised by the dietician. Results: Body mass index and body fat mass remained unchanged during the 4 months of dietary treatment. Urea, leptin, and TNF‐alpha serum concentrations decreased significantly. Conclusions: A low protein, low phosphorus diet reduces TNF‐alpha and leptin levels in plasma. The effect on leptin appears not to be mediated by an insulin‐dependent mechanism.