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Acute renal tubular injury with acute hepatitis A infection: Is it just a coincidence?
Author(s) -
SHROFF GAUTAM R,
BADVE SUNIL V,
JOSHI ANAND G,
DESAI DEVENDRA C,
ABRAHAM PHILIP,
SIRSAT RASIKA A
Publication year - 2004
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2003.00224.x
Subject(s) - medicine , acute tubular necrosis , dialysis , acute kidney injury , fulminant hepatitis , renal function , fulminant , necrosis , hepatitis , gastroenterology
SUMMARY: Acute renal failure has rarely been reported in association with acute hepatitis A infection. The commonest form of renal injury in such patients has been found to be acute tubular necrosis. We report two cases of hepatitis A infection in which acute renal failure occurred very early in the course of the illness and had a clinical presentation and recovery pattern suggestive of acute tubular necrosis. In both patients, the clinical course of renal dysfunction was almost parallel to the course of hepatic dysfunction. Patient 1 needed dialysis, whereas patient 2 did not need dialysis and had a very rapid recovery from renal function in spite of having more severe azotaemia. Patient 2 was administered acetylcysteine in high doses for suspected fulminant hepatic failure. A potential benefit of a high dose of acetylcysteine in recovery of renal function from acute tubular necrosis is postulated.