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Cigarette smoking accelerates progression of renal failure in primary renal disease. A prospective study in parallel group design with matched groups
Author(s) -
Schiffl Helmut,
Lang Susanne M,
Fischer Rainald,
Bergner Albrecht
Publication year - 2000
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2000.00015.x
Subject(s) - medicine , hemodialysis , catheter , surgery , population , dialysis , subclavian vein , internal jugular vein , vein , thrombosis , femoral vein , dialysis catheter , hemodialysis catheter , kidney disease , central venous catheter , environmental health
SUMMARY There is substantial evidence for the adverse impact of smoking on deterioration of renal function in diabetic nephropathy but very little information is available concerning effects of smoking on the evolution of other renal diseases. In a prospective study in parallel group design with matched groups, 45 cigarette smoking patients (≥ 1 pack/day) with glomerular or tubulointerstitial lesions were compared with 45 non‐smoking patients matched for age, gender, cause and severity of renal disease as well as presence of hypertension. The monthly decline of creatinine clearance was significantly faster in smoking patients than in non‐smoking patients (follow‐up period 2 years) (1.25 mL/min vs 0.67 mL/min, P < 0.001). Smoking promoted progression of both glomerular and tubulointerstitial nephropathy. This effect occurred independently of changes in blood pressure, proteinuria or lipid concentration. The results of this investigation indicate that cigarette smoking is an independent risk factor not only for diabetic but also for non‐diabetic nephropathies.