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Polymorphism of renin‐angiotensin system genes in progressive IgA nephropathy
Author(s) -
YOSHIDA Hiroaki,
KAWAMURA Tetsuya,
ICHIKAWA Iekuni,
SAKAI Osamu
Publication year - 1997
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1997.tb00290.x
Subject(s) - medicine , nephropathy , proteinuria , renal function , allele , renin–angiotensin system , angiotensin converting enzyme , peptidyl dipeptidase a , endocrinology , gene , kidney , genetics , biology , blood pressure , diabetes mellitus
Summary: Clinical studies revealed that angiotensin converting enzyme (ACE) inhibitor reduces proteinuria and attenuates progressive decline in renal function in IgA nephropathy. Recent studies by us and others have demonstrated that the homozygote of the D allele (DD) of the ACE insertion/deletion (I/D) polymorphism is a potential risk factor for poor prognosis in IgA nephropathy, and that this deletion polymorphism predicts the therapeutic efficacy of ACE inhibition on proteinuria and, potentially, on progressive deterioration of renal function in patients with the nephropathy.