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Histological classification of IgA nephropathy: Grading and staging
Author(s) -
SHIGEMATSU Hidekazu
Publication year - 1997
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1997.tb00289.x
Subject(s) - medicine , nephropathy , grading (engineering) , fibrosis , pathology , lesion , glomerulosclerosis , inflammation , stage (stratigraphy) , kidney , proteinuria , paleontology , civil engineering , engineering , biology , diabetes mellitus , endocrinology
Summary: More than 30% of IgA nephropathy cases progress to end‐stage renal failure within 20 years. Histologically this disease is made up of at least three types of tissue damage: (i) minimal inflammation including deposition of IgA containing substances with minor matricial increase; (ii) acute lesions characterized by matricial damage with inflammatory cell accumulation; and intrinsic cell proliferation; and (iii) chronic lesion, mainly composed of postinflammatory sclerosis. Progression is accelerated by the frequency of acute lesions, resulting in the increased glomerular sclerosis. the histologic grading and staging (G‐S system) aims to enhance our understanding of IgA nephropathy. the histological grade (G) is estimated by the extent of acute glomerular and tubulointerstitial lesions, while the stage (S) is evaluated by the increase of extracellular matrices of the glomeruli and interstitial fibrosis. the evaluation of the G and S is expressed semiquantitatively for more helpful use in the clinical side.