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Renin‐angiotensin system component gene polymorphisms in Japanese maintenance haemodialysis patients
Author(s) -
KAWADA Noritaka,
MORIYAMA Toshiki,
YOKOYAMA Kenji,
YAMAUCHI Atsushi,
ANDO Akio,
MIKAMI Hiroshi,
FUJII Masamitu,
KAJIMOTO Yoshiteru,
HORIO Masaru,
IMAI Enyu
Publication year - 1997
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1997.tb00236.x
Subject(s) - medicine , allele , renin–angiotensin system , angiotensin converting enzyme , genotype , endocrinology , allele frequency , end stage renal disease , population , dialysis , kidney disease , disease , genetics , gene , biology , blood pressure , environmental health
Summary: The renin‐angiotension system (RAS) component gene polymorphisms was examined in 216 patients undergoing maintenance haemodialysis (HD) therapy and in 208 control subjects. the RAS polymorphisms selected for analysis were angiotensin I converting enzyme (ACE) I/D, angiotensinogen (Agt) T235/M235, angiotensin II type 1 receptor (AGT1R) A1166/C1166. the control allelic frequencies was ACE I/D (0.63/0.37), Agt T235/M235 (0.16/0.84), and AGT1R A1166/C1166 (0.94/0.06). Recently, relationships between ACE I/D and the progression of renal disease attract great attention in Japanese and Caucasian populations. ACE D allele was expected to be more frequent in HD population. However, no accumulation of ACE D allele or Agt T235 allele, AFT1R C1166 allele in Japanese end‐stage renal disease (ESRD) subjects was detected. to explain the paradoxical result of positive association of ACE D allele with progression of renal disease and no bias of ACE genotype in ESRD subjects, further investigation with systematic prospective study regarding the change of ACE genotype distribution around the period of entering dialysis therapy is required.