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Role of cytokines in the progression of renal damage in IgA nephropathy
Author(s) -
SCHENA FP
Publication year - 1997
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1997.tb00192.x
Subject(s) - medicine , nephropathy , immune system , chemokine , glomerulosclerosis , pathophysiology , immunology , fibrosis , kidney disease , disease , kidney , proteinuria , glomerulonephritis , focal segmental glomerulosclerosis , pathology , endocrinology , diabetes mellitus
Summary: IgA nephropathy, or Berger's disease (IgAN), is a worldwide disease which is characterized by a slowly progressive loss of renal function accompanied by decreasing kidney size with the development of glomerulosclerosis and interstitial fibrosis. Immunologic and non‐immunologic factors are implicated in the progression of renal damage, since they are potent inducers in stimulating glomerular, tubular and interstitial cells and non‐resident cells to produce free oxygen radicals, cytokines, growth factors, chemokines, etc. Recent data from our laboratory and other groups, synthesized in this review, have demonstrated the remarkable involvement of these humoral factors in the progression of renal damage in IgAN patients. Therefore, prospective therapeutic approaches have been suggested in blocking the inflammatory mediators during the pathophysiologic sequelae of immune and non‐immune mechanisms which may intervene in the outcome of the disease.