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Free radical release and progression of renal failure
Author(s) -
RODRIGUEZ GILBERTO E,
YI ZHU WEN,
KRIEG RICHARD J,
CHAN JAMES CM
Publication year - 1996
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1996.tb00159.x
Subject(s) - medicine , nephropathy , pathogenesis , disease , glomerulonephritis , kidney , gastroenterology , immunology , endocrinology , diabetes mellitus
Summary: IgA nephropathy, formerly known as Berger's Disease, is now recognized as the world's most common primary nephropathy. the rate of progression has recently been shown to be the same in childhood as well as adulthood (i.e. slightly more than 1/4 of the patients had end‐stage renal disease at follow up of 20 years). the pathogenesis may be associated with free‐radical release as demonstrated in experimental IgA nephropathy and indirectly in leucocytes of these patients. the use of vitamin E and fish oil is discussed.