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Neurohormonal factors in the pathogenesis of essential hypertension
Author(s) -
NICHOLLS M GARY,
RICHARDS A MARK
Publication year - 1996
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1996.tb00142.x
Subject(s) - medicine , adrenomedullin , pathogenesis , essential hypertension , pathophysiology of hypertension , endothelins , pathophysiology , nitric oxide , arterial stiffness , vasodilation , bioinformatics , blood pressure , endothelin receptor , receptor , biology
Summary: The level of arterial pressure in an individual is dictated by many interacting factors including neurohormonal systems. Heightened activity of pressor systems could contribute to the pathogenesis of essential hypertension; evidence for this is strongest for sympathetic overactivity in some young patients. Inadequacy of vasodilator systems, especially natriuretic peptides or nitric oxide, has also been suggested as central to the pathogenesis of essential hypertension although evidence is far from definitive. the existence of authentic ouabain in human plasma, let alone its pathophysiological importance in hypertension, is now in doubt. Information is awaited regarding the role of the endothelins and adrenomedullin in physiology and in essential hypertension.