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Matrix accumulation in diabetic nephropathy: Studies by confocal microscopy
Author(s) -
BECKER G,
BIRCHALL I,
CHEN YP,
GROSS J
Publication year - 1996
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1996.tb00140.x
Subject(s) - immunoperoxidase , medicine , confocal microscopy , confocal , microscopy , confocal laser scanning microscopy , matrix (chemical analysis) , laser microscopy , nephropathy , pathology , diabetic nephropathy , core (optical fiber) , laser , optics , biomedical engineering , diabetes mellitus , kidney , materials science , endocrinology , immunology , physics , monoclonal antibody , composite material , antibody
Summary: Confocal scanning laser microscopy (CSLM) has the potential to provide new insights into matrix deposition in renal pathology. For example laser stimulated light emission from Kimmelstiel Wilson (KW) nodules emphasizes a difference between peripheral and central nodule contents, an observation matching immunoperoxidase studies, which fails to demonstrate high density of renal matrix proteins in the core.