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Relationship between obstruction of arteriovenous fistula and plasma level of endothelin‐1 in long‐term haemodialysis patients
Author(s) -
ONO Takahiko,
NAGAI Hiroyuki,
KANATSU Kazuro,
KUDOH Tetsuhiro,
ONOE Chika,
UTSUNOMIYA Kazumasa,
HARA Akira,
MATSUOKA Satoru,
MATSUSHIMA Hiroyuki,
MUSO Eri,
SASAYAMA Shigetake
Publication year - 1996
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1996.tb00096.x
Subject(s) - medicine , fistula , arteriovenous fistula , endothelin receptor , endothelin 1 , erythropoietin , stenosis , gastroenterology , surgery , urology , receptor
Summary: The relationship between the patency status of the autogenous arteriovenous (A‐V) fistula and the plasma level of endothelin‐1 (ET‐1) was studied in 41 patients who had been receiving routine longterm haemodialysis for more than 10 years. the ET‐1 level in the haemodialysis patients (mean ± s.d.=2.1 ± 0.9 pg/mL) was significantly elevated compared with that in healthy controls ( n =16; 1.1 ± 0.4 pg/mL; P < 0.01). the patients were classified into two groups according to whether the original A‐V fistula had remained patent for more than 10 years or had been repaired due to frequent (more than twice) obstruction. Among all 41 patients, 21 were receiving recombinant human erythropoietin (rHuEpo) intravenously (i.v.). In the rHuEpo‐treated group, the plasma ET‐1 ( n =21; 2.4 ± 0.8 pg/mL) was significantly elevated than that in the rHuEpo‐untreated group ( n =20; 1.9 ± 0.9 pg/mL; P<0.05). After exclusion of the 21 rHuEpo‐treated patients, the ET‐1 level in the repaired fistula group ( n =11; 2.3 ± 0.9 pg/mL) was significantly higher than that in the patent original fistula group ( n =9; 1.3 ± 0.7 pg/mL; P <0.02). Based on these results, we conclude that ET‐1 shows a close relation to venous stenosis of the A‐V fistula which may be due to its vasoconstrictive and smooth muscle cell‐proliferating effects.