Premium
Human renal allograft rejection: Immune mechanisms, molecular correlates and treatment strategies
Author(s) -
SUTHANTHIRAN Manikkam,
STROM Terry B
Publication year - 1996
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1996.tb00060.x
Subject(s) - medicine , cytotoxic t cell , immune system , immunology , cd8 , effector , graft rejection , transplantation , organ transplantation , antibody , kidney transplantation , transplant rejection , t cell , biology , biochemistry , in vitro
Summary: Through the release of cytokines and cell‐to‐cell interactions, a diverse assembly of lymphocytes, including CD4+ cells, CD8+ cytotoxic T cells, antibody‐forming B cells, and other pro‐inflammatory leucocytes are recruited into the anti‐allograft response. In this review, we discuss immune effector mechanisms, molecular correlates of rejection and therapeutic protocols. the recent expansion in our knowledge, coupled with the discovery and use of new immunosuppressants in the clinic, engenders optimism regarding management of allograft rejection, the most serious frequent complication in organ transplantation.