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Effects of renal denervation on cyclosporin induced hypertension in the Wistar rat
Author(s) -
MARTIN Allison,
LI Ming,
TURNER Steven W.,
WHITWORTH Judith A.
Publication year - 1995
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1995.tb00029.x
Subject(s) - denervation , medicine , plasma renin activity , blood pressure , kidney , creatinine , endocrinology , renal function , urology , renin–angiotensin system
Summary: The effects of renal denervation were examined in cyclosporin A (CyA) treated Wistar rats 14 days prior to 1 day prior to and 10 days after CyA was administered. the rise in blood pressure was attenuated when the renal denervation was performed 1 day prior to and 10 days after administration, but not 14 days prior to CyA, presumably reflecting re‐innervation of the kidney. Plasma renin activity (PRA) was increased by CyA 10 mg/kg per day and 20 mg/kg per day, but decreased by renal denervation 1 day prior to CyA. Plasma creatinine was increased by CyA at 10 mg/kg per day and decreased by renal denervation 1 day prior to CyA. These data support the notion that renal sympathetics play a role in CyA induced hypertension.