Premium
Central nervous system marginal zone B ‐cell lymphoma of mucosa‐associated lymphoid tissue type involving the brain and spinal cord parenchyma
Author(s) -
Ueba Tetsuya,
Okawa Masakazu,
Abe Hiroshi,
Inoue Tooru,
Takano Koichi,
Hayashi Hiroyuki,
Nabeshima Kazuki,
Oshima Koichi
Publication year - 2013
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.2012.01350.x
Subject(s) - pathology , spinal cord , parenchyma , medicine , central nervous system , lymphoma , biopsy , brain biopsy , marginal zone , lymphatic system , immunohistochemistry , b cell , antibody , immunology , psychiatry , endocrinology
We present a case of a 53‐year‐old HIV negative man with a 2‐month history of progressive recent memory disturbance, gait disturbance and urinary incontinence. On MRI , an infiltrative tumor in the brain and spinal cord was noted. Subsequent positron emission tomography studies along with bone marrow biopsy and serum protein electrophoresis showed no evidence of systemic disease. Open brain biopsy results revealed a small lymphocytic infiltrate with scattered plasma cells in a predominantly perivascular growth pattern. The morphology was consistent with involvement by a low‐grade B ‐cell lymphoma. Immunohistochemical findings showed CD 20+, CD 10–, CD 5–, TdT –, EBV –encoded RNA in situ – and IgM –. The above findings were consistent with involvement by a non‐dural extranodal marginal zone B ‐cell lymphoma ( MZBCL ) primary to the brain and spinal cord. This is a case report of a CNS MZBCL of mucosa‐associated lymphoid tissue type involving the brain and spinal cord parenchyma.