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An intracranial malignant solitary fibrous tumor
Author(s) -
Choi ChanYoung,
Han SeongRok,
Yee GiTaek,
Joo Mee
Publication year - 2011
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.2010.01148.x
Subject(s) - pleomorphism (cytology) , vimentin , solitary fibrous tumor , pathology , cd34 , medicine , cytokeratin , immunophenotyping , high power field , immunohistochemistry , biology , antigen , stem cell , immunology , genetics
Intracranial malignant solitary fibrous tumor (SFT) is very rare. It was identified in a 39‐year‐old female patient who underwent malignant transformation over 6 months. MRI revealed an 8 × 5 × 6 cm mass with heterogenous strong enhancement in the left occipital lobe. Histologic findings and immunophenotype (positive for CD34, bcl‐2 and vimentin, and negative for epithelial membrane antigen or S100 protein) of the primary tumor were typical of SFT. However, there was a focal area (<10% of tumor volume) showing hypercellularity, nuclear pleomorphism and increased Ki‐67 labeling index (LI) of 10% (average, 1%). At the second operation, the recurrent tumor revealed full‐blown histologic features of malignant SFT, such as infiltrative brain invasion, marked nuclear pleomorphism, frequent mitotic figures (15/10 high power fields), and high Ki‐67 LI (25%). The presence of atypical histologic finding or increased Ki‐67 LI in the typical SFT, although it is focal, needs to be mentioned in the diagnosis and also may require more aggressive surgical management.