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Pathology of protein synthesis and degradation systems in ALS
Author(s) -
Okamoto Koichi,
Fujita Yukio,
Mizuno Yuji
Publication year - 2010
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.2009.01088.x
Subject(s) - autophagy , ubiquitin , protein degradation , organelle , cytoplasm , neuroscience , microbiology and biotechnology , biology , medicine , pathology , biochemistry , apoptosis , gene
Protein synthesis and degradation systems in neurons are among the major subjects of study in neurobiology. These systems are believed to be the main pathways involved in ALS; however, the essential pathomechanisms that underlie this disease remain obscure. In addition to the ubiquitin‐proteasomal and autophagic systems, several cytoplasmic organelles are also involved in ALS. Here, we present our data and discuss the main morphological abnormalities detected in the anterior horn cells of ALS patients.