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Papillary glioneuronal tumor
Author(s) -
Gelpi Ellen,
Preusser Matthias,
Czech Thomas,
Slavc Irene,
Prayer Daniela,
Budka Herbert
Publication year - 2007
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.2007.00802.x
Subject(s) - histogenesis , olig2 , nestin , pathology , immunohistochemistry , biology , immunophenotyping , subependymal zone , oligodendrocyte , medicine , stem cell , central nervous system , neural stem cell , neuroscience , antigen , microbiology and biotechnology , myelin , immunology
Papillary glioneuronal tumor (PGNT) is a rare, recently recognized tumor type histologically characterized by pseudopapillary architecture associated with compact areas composed of neuronal elements in different maturation states. The histogenesis of this tumor type is still unclear. The immunophenotype of PGNT comprises expression of several glial and neuronal proteins. Recently, immunohistochemical expression of Olig2 in a fraction of tumor cells has been reported, suggesting an additional oligodendroglial or at least oligodendroglia‐like tumor cell component. We report a further case of papillary glioneuronal tumor in a 12‐year‐old boy with immunohistochemical expression of PDGFRα, Olig2 and Nestin in support of a postulated origin of this tumor type from common progenitor cells in the subependymal plate. Nevertheless, further studies are needed to clarify the histogenesis of PGNT.