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Spinal atypical teratoid/rhabdoid tumor in a 7‐year‐old boy
Author(s) -
Yang ChiiShuenn,
Jan YeeJee,
Wang John,
Shen ChiungChyi,
Chen Clayton C.C.,
Chen Ming
Publication year - 2007
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.2007.00752.x
Subject(s) - cd99 , vimentin , cytokeratin , pathology , atypical teratoid rhabdoid tumor , immunohistochemistry , fluorescence in situ hybridization , biology , neurofilament , in situ hybridization , medicine , chromosome , messenger rna , gene , biochemistry
Reported herein is an unusual case of atypical teratoid/rhabdoid tumor (AT/RT) of the lumbar spine with an intradural extramedullary location in a 7‐year‐old boy. Histologically, this tumor contained rhabdoid cells, pale cells, and sickle‐shaped embracing cells without primitive neuroectodermal tumor (PNET), mesenchymal or epithelial components. Immunohistochemical staining showed that these tumor cells react positively for epithelial membrane antigen (EMA), vimentin, cytokeratin (AE1/AE3), CD99 and neurofilament protein, but negatively for INI1 antibody. Chromosome 22q deletion was demonstrated on fluorescence in situ hybridization.