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Low‐grade follicular lymphoma in the dura: Rare mimic of meningioma
Author(s) -
Low Irene,
Allen Jonathan
Publication year - 2006
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.2006.00730.x
Subject(s) - medicine , pathology , lymphoma , follicular lymphoma , meningioma , dura mater , infiltration (hvac) , lumbar , meninges , radiology , physics , thermodynamics
Lymphomas rarely present as a localized mass within the dura. We report a case of a 72‐year‐old woman, normally fit and well, who presented with a sudden episode of grand mal seizure. Imaging studies showed an extra‐axial mass arising from the dura, with radiologic features characteristic of a meningioma. The mass was surgically excised, and the histologic features were of a grade 1 follicular lymphoma. Analysis using fluorescent in situ hybridization (FISH) demonstrated t(14:18) translocation. A bone marrow aspirate showed focal infiltration of lumbar vertebra by low‐grade follicular lymphoma. Intracranial meningeal involvement by non‐Hodgkin lymphoma usually occurs in the form of diffuse leptomeningeal spread. It is seen in high‐grade lymphomas, often in association with widespread systemic disease. The majority of cases of dural lymphomas reported in the literature have been primary mucosa‐associated lymphoid tissue (MALT)‐type lymphomas. Most of these presented as localized dural masses mimicking meningiomas. Low‐grade follicular lymphoma, either primary or secondarily involving the dura, appears to be an exceedingly rare occurrence.