Premium
Causes of neuronal heterotopia other than migration disturbances
Author(s) -
Hori Akira
Publication year - 2006
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.2006.00729.x
Subject(s) - heterotopia (medicine) , white matter , anatomy , pathology , dentate nucleus , neuroscience , trisomy , biology , cerebellum , medicine , genetics , magnetic resonance imaging , radiology
A differentiated form of cerebellocortical fragments (case 1) in the white matter or even in the cerebellar dentate nucleus, found in a fetus with trisomy 13, may be due to an auto‐transplantation accompanied by a penetrating vessel. A similar condition was observed in the Ammon’s horn (case 2) incidentally as a heterotopic tissue fragment of the dentate fascia. Further cause of heterotopia may be speculated as a mechanical separation by a surrounding and developing tissue part in case of organized, differentiated cerebellocortical heterotopia in the white matter (cases 3–5) which were clinically silent. Migration disturbances are not the only cause of neuronal heterotopia since the structure of heterotopia is differentiated and organized by tissue components.