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Dynamic analysis of glioma cells: Looking into “movement phenotypes”
Author(s) -
Suzuki Satoshi O.,
Iwaki Toru
Publication year - 2005
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.2005.00626.x
Subject(s) - glioma , neuroscience , phenotype , lesion , cell , intracellular , biology , pathology , medicine , cancer research , microbiology and biotechnology , biochemistry , genetics , gene
One of the major obstacles to the successful treatment of diffuse gliomas is their highly infiltrative property. It is one of the important therapeutic strategies to inhibit infiltration of glioma cells and make it possible to locally control a lesion. To achieve this, we first need to observe and describe detailed movement profiles of glioma cells in the brain tissue at the cellular level. Then we further need to determine extra and intracellular molecules that play a key role in glioma cell invasion. Live cell imaging is a powerful technique to investigate the basic movement pattern of glioma cells as well as the effects of therapeutic interventions on their migration. In this review, we describe a technical aspect of live cell imaging with special regard to time‐lapse video imaging and discuss the relevance of the methods to glioma studies.