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Epithelioid malignant peripheral nerve sheath tumor involving maxillary sinus
Author(s) -
IzyckaSwieszewska Ewa,
Drogoszewska Barbara,
Filipowicz Joanna,
Szurowska Edyta,
Kaminski Maciej,
Jaskiewicz Kazimierz
Publication year - 2005
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.2005.00619.x
Subject(s) - malignant peripheral nerve sheath tumor , pathology , medicine , vimentin , maxillary sinus , enolase , biopsy , epithelioid cell , immunohistochemistry , neoplasm , peripheral , anatomy
We present a case of epithelioid malignant peripheral nerve sheath tumor (MPNST) located in the maxillary sinus region in a young man. The clinical history was short, but at admission the neoplastic infiltration was so extensive that only diagnostic biopsy was performed. The patient received palliative treatment and died 6 months later. Histologically, the neoplasm had a predominant epithelioid component. Neoplastic tissue was vimentin, S‐100, Cam 5.2 and neuron‐specific enolase positive. P53 protein reaction was found in 6% of the cells and the proliferation index assessed with Ki‐67 was 52%. An appropriate immunohistochemical panel was essential for the final diagnosis of this epithelioid malignant tumor, with the location rather unusual for MPNST.