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Muscle biopsy of a 15‐year‐old boy with muscle atrophy and weakness of the extremities from infancy
Author(s) -
Shirabe Teruo
Publication year - 2001
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.2001.00371.x
Subject(s) - neuropathology , muscle biopsy , weakness , medicine , atrophy , anatomy , biopsy , pathology , disease
unstained central core with a deeply stained rim in the center of each muscle fiber (Fig. 1b). The central core was weakly stained by Gomori trichrome (Fig. 1c), cytochrome c oxidase (Fig. 1d) and PAS (Fig. 1E) staining. Acid phosphatase activity was increased in the core (Fig. 1f). In the ATPase-stained sections almost all the muscle fibers were shown to be type 1. Electron microscopically, myofilaments outside of the central core were not disarranged and Z disks ran at right angles to the myofilament array. Inside of the cores, however, myofilaments and Z disks were disarranged (Fig. 2). Mitochondria and glycogen granules were greatly decreased. At the edge of the cores, swollen mitochondria and an increase in glycogen granules were observed.