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Meningeal large granular lymphocyte lymphoma
Author(s) -
Nagashima Toshiko,
Mori Masamitsu,
Kazumata Ken,
Fujimoto Makoto,
Kuroda Bin,
Nunomura Mitsuru,
Shinohara Toshiya,
Hasegawa Hideki,
Watanabe Yoshiaki,
Tanaka Shinya,
Nagashima Kazuo
Publication year - 1998
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1998.tb00124.x
Subject(s) - pathology , lymphoma , autopsy , parenchyma , cd43 , lymphocyte , azurophilic granule , epstein–barr virus , biology , virus , medicine , immunology , inflammation , cd20 , myeloperoxidase
A 57‐year‐old man who presented with leptomeningeal lymphoma was reported. The lymphoma cells in the cere‐brospinal fluid were large in size, had atypical nuclei and contained many azurophilic granules in their pale cytoplasm, all of which were consistent with malignant lymphoma of large granular lymphocytes (LGL). Immunohistochemically, tumor cells were positive for cyto‐plasmic CD3, UCHL‐1, and CD56, markers of natural killer (NK)cells. Epstein‐Barr virus encoded small RNA (EBER) was detected in tumor cells by in situ hybridization. No evidence of parenchymal central nervous system or systemic tumor was identified, although at autopsy microscopic lympuoma involvement was found in the pituitary gland and kidney. To our knowledge this is the first autopsy case report of primary meningeal LGL lymphoma.