Premium
Alteration in hippocampal and cerebral expression of glial fibrillary acidic protein following styrene exposure in rat
Author(s) -
Wang Yuping,
Saito Takeshi,
Hosokawa Toshiyuki,
Saito Kazuo
Publication year - 1998
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1998.tb00117.x
Subject(s) - glial fibrillary acidic protein , hippocampus , cerebral cortex , gfap stain , hippocampal formation , styrene , cortex (anatomy) , immunohistochemistry , central nervous system , chemistry , pathology , biology , neuroscience , medicine , organic chemistry , copolymer , polymer
In order to investigate the neuropathological effects on the central nervous system of the rat by styrene exposure, identification of glial fibrillary acidic protein (GFAP) was observed using immunohistochemical staining and confocal laser scanning microscopy in the rat treated with styrene at 400 mg/kg and 800 mg/kg for 2 weeks. Both styrene‐treated groups showed a marked increase of GFAP expression in cerebral cortex and hippocampus compared with the control group. These changes showed a dose‐ and time‐dependent manner. Increased expression of GFAP in cerebral cortex and hippocampus provided the effects of styrene on the structüre of cerebral cortex and hippocampus objectively.