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Herpes encephalitis and paraneoplastic limbic encephalitis
Author(s) -
Nagashima Kazuo,
Kobayashi Yoshiyasu,
Kojima Hideaki,
Hasegawa Hideki,
Kurata Takeshi
Publication year - 1998
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1998.tb00103.x
Subject(s) - limbic encephalitis , encephalitis , limbic system , herpes simplex virus , pathology , pathological , medicine , autopsy , limbic lobe , virology , virus , immunology , central nervous system , neuroscience , biology
Pathological examination of four autopsy cases of herpes simplex virus encephalitis reconfirmed that the inflammatory necrotizing lesions occurred predominantly in the limbic system. This site predilection can be explained by the viral spread via the olfactory pathway, or along the meningeal branches of the trigeminal nerves and by the localization of specific herpes virus receptors. Case studies of non‐herpetic paraneoplastic limbic encephalitis were briefly introduced and the results suggest that a specific protein recognized by antibody exists in the limbic system. Thus, both virological and immunological evidence suggests that the human limbic system has specific proteins which are unique in the human brain.