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Alzheimer's disease as a polygenic disease
Author(s) -
Okuizumi Kaoru,
Tsuji Shoji
Publication year - 1998
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1998.tb00087.x
Subject(s) - disease , apolipoprotein e , allele , identification (biology) , genetics , medicine , alzheimer's disease , biology , gene , bioinformatics , pathology , botany
Recent advances in molecular genetics have enabled the identification of the causative genes for early‐onset familial Alzheimer's disease (AD). However, sporadic and late‐onset familial AD, the most common forms of AD, are considered to be polygenic disorders. The presence of APOE4 , one of the specific alleles of the apolipoprotein E gene, has been established as a major genetic risk factor for the development of AD. Additional risk factors are under active investigation. Such new approaches are expected to establish preventive measures or treatments for AD.