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Concurrence of amyotrophic lateral sclerosis with limbic degeneration and Alzheimer's disease
Author(s) -
Yamashita Mariko,
Yamamoto Toru,
Nakamura Kimihiro
Publication year - 1997
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1997.tb00062.x
Subject(s) - amyotrophic lateral sclerosis , degeneration (medical) , atrophy , medicine , senile plaques , pathology , limbic system , dysarthria , dysphagia , dementia , cerebral cortex , neuroscience , alzheimer's disease , disease , psychology , audiology , central nervous system , surgery
A 72‐year‐old woman developed dysarthria and dysphagia followed by weakness and atrophy in the limb muscles. Later the patient showed mild dementia and died 17 months after the onset. Postmortem examination revealed typical findings of amyotrophic lateral sclerosis (ALS) consisting of extensive involvement of both upper and lower motor neurons and severe limbic degeneration. In addition, abundant neurofibrillary tangles (NFT) and senile plaques (SP) were seen throughout the cerebral cortex, which were compatible with Alzheimer's disease (AD). This is the first reported case of definite AD and ALS with limbic degeneration.