Premium
Central nervous system lymphoma and Epstein‐Barr virus in immunocompetent patients in Thailand
Author(s) -
Kasantikul Vira,
Mutirangura Apiwat,
Wannakrairot Pongsak,
Pornthanakasem Wichai,
Ruangvejvorachai Preecha,
Sriuranpong Virote,
Voravud Narin
Publication year - 1997
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1997.tb00056.x
Subject(s) - lymphoma , immunophenotyping , immunosuppression , pathology , epstein–barr virus , primary central nervous system lymphoma , immunohistochemistry , medicine , central nervous system , virus , polymerase chain reaction , non hodgkin's lymphoma , immunocompetence , herpesviridae , immunology , biology , viral disease , immune system , gene , biochemistry , flow cytometry
A series of 11 apparently immunocompetent patients with primary non‐Hodgkin's lymphoma of the central nervous system (NHL‐CNS) together with six patients with systemic lymphoma involving the spinal cord and/or brain were studied for immunophenotyping and the presence of Epstein‐Barr virus (EBV). Immunohistochemistry and polymerase chain reaction (PCR) were performed on paraffin‐embedded tissues. Nine of 11 primary NHL‐CNS and all six secondary CNS lesions were of B cell origin. The EBV sequences were detected in six primary tumors and four systemic lesions by PCR while the immuno‐histochemical marker for the EBV‐latent membrane protein was positive in five primary lesions and three secondary neoplasms. Our results suggest that the association of EBV and NHL‐CNS is not only restricted to patients with immunosuppression but that it includes a broad spectrum of conditions in which this relationship occurs in patients without immunodeficiency. The mortality rate is high particularly in patients with EBV‐associated NHL‐CNS.