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Gene analysis of retrograde degeneration
Author(s) -
Miyake Toshihiko,
Gahara Yoshinari,
Uwabe KenIchiro,
Yamada Hajime,
Kitamura Tadahisa
Publication year - 1997
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1997.tb00030.x
Subject(s) - axotomy , degeneration (medical) , neurodegeneration , neuropathology , gene , biology , wallerian degeneration , neuroscience , regeneration (biology) , pathology , central nervous system , medicine , microbiology and biotechnology , genetics , disease
Retrograde degeneration of neurons following axotomy is an excellent experimental model of neurodegeneration. Using this model, molecular biological techniques have demonstrated a number of specific genes to be involved in the pathological processes of degeneration, regeneration, and repair which occur after axotomy. Further insight into gene involvement in these processes can be gained using the recently developed methods for screening genes whose expression is up‐ or down‐regulated after injury. These methods have successfully identified many genes to be markedly regulated and thus significantly involved in retrograde degeneration of the rat facial nucleus after axotomy of the facial nerve. Some are novel genes not previously identified, and others are genes already documented but their involvement in neuropathology not previously evaluated. Elucidation of the function of these genes would aid studies on the pathology of retrograde degeneration and provide important information on degenerative disorders of the human nervous system.