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Similarities and differences among progressive among progressive supranuclear palsy, corticobasal degeneration and Pick's disease
Author(s) -
Wakabayashi Koichi,
Takahashi Hitoshi
Publication year - 1996
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1996.tb00192.x
Subject(s) - corticobasal degeneration , progressive supranuclear palsy , pathology , pick's disease , pathological , neuroscience , atrophy , medicine , disease , dementia , psychology
Corticobasal degeneration CBD) bears some resemblance to progressive supranuclear palsy (PSP) with regard to its widespread neuroal and glial cytoskeletal abnormalities. In addition, CBD and Pick's disease (PD) are both characterized by circumscribed cerebral atrophy and cortical ballooned neurons. Clinically, all three disease can present with a dementia and may be confused with each other. We examined the morphology and differential distribution of glial fibrillary tangles in PSP ( n = 10), CBD ( n = 3) and PD with Pick bodies ( n = 2). Ballooned neurons were found in two cases of PSP but were much fewer than those found in the CBD or PD. Althought the subcortical lesions in PSP and CBD were similar, the involvement of the subthalamic and dentate nuclei was less severe in the latter. Gallyas‐Breaak method revealed that tuft‐shaped astrocytes were found almost exclusively in PSP, whereas astrocytic plaques were specific for CBD. None or few argyrophilic structures were visualized in PD. These findings indicate that each disorder is a distinct pathological entity. It is possible that a subpopulation of previous cases reported as unusual case of PD without Pick bodies may be additional examples of CBD.