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Astroglial reaction pattern in human immunodeficiency virus type 1 infected brains
Author(s) -
Itoh Kyoko,
Mehraein Parviz,
Weis Serge
Publication year - 1996
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1996.tb00186.x
Subject(s) - glial fibrillary acidic protein , immunohistochemistry , astrocyte , biology , pathology , virus , human immunodeficiency virus (hiv) , neuroglia , virology , human brain , immunology , central nervous system , medicine , neuroscience
The reaction pattern of astrocytes was investigated by means of immunohistochemistry and morphometry in 36 brain regions of human immunodeficiency virus type 1 infected patients and of normal controls. The numerical density of astrocytes immunoreactive for glial fibrillary acidic protein (GFAP) was determined. In HIV1 infected brains, the number of GFAP‐positive astrocytes was significantly increased in all investigated brain regions as compared with normal controls. The increase in number of GFAP‐positive, reactive astrocytes might play a crucial role in triggering pathogenetic mechanisms leading to cell damage and death in HIV1 infected brains.