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Abnormal glial cytoskeleton in progressive supranuclear palsy
Author(s) -
Amano Naoji,
Takahashi Tatsuya,
Yagishita Saburo,
Inoue Masayuki,
Matsushita Masaaki
Publication year - 1996
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1996.tb00169.x
Subject(s) - astrocytosis , progressive supranuclear palsy , brainstem , neuroscience , pathology , cerebellum , gliosis , cytoskeleton , biology , basal ganglia , medicine , disease , central nervous system , cell , genetics
Progressive supranuclear palsy (PSP) is characterized by neurodegenerative changes of the basal ganglia, brainstem and the cerebellum. Moreover, it is noteworthy that abnormal cytoskeleton of glial cells is distributed widely in the brain. The morphological, immunohistochemical and ultrastructural properties of the properties of the peculiar glia have been elucidated. However, many factors remain unsettled regarding the abnormalities. The purpose of this paper is to define the properties of PSP, to present its distributional characteristics, and to examine the correlation of PSP with neuronal loss and astrocytosis.