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Argyrophilic meshwork structures in the cerebral cortex of patients with progressive supranuclear palsy
Author(s) -
Komori Takashi,
Shibata Noriyuki,
Kobayashi Makio,
Sasaki Shoichi
Publication year - 1996
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1996.tb00146.x
Subject(s) - progressive supranuclear palsy , cerebral cortex , trabecular meshwork , pathology , anatomy , ultrastructure , biology , medicine , neuroscience , atrophy , glaucoma
We describe the presence of tau protein‐positive argyrophilic meshwork structures in the cerebral corticomedullary junctions of three patients with progressive supranuclear palsy (PSP). Meshwork structures are composed of fine, winding fibrils, partly connected to coiled inclusions in oligodendrocytes, and are present on neurofilament protein‐positive axons. The novel abnormal structures are numerous in the middle frontal and precentral gyri, and at the ultrastructural level they are present mainly in the outer myelin sheath. Our results suggest that the unusual meshwork structures are formed in processes of oligodendroglia in the cerebral cortex. Further study of well characterized cases is required in order to determine the significance of these structures in cerebral cortical functions in patients with PSP.