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Amyloid P component immunoreactivity in brains of Alzheimer‐type dementia is reduced by formic acid pretreatment on tissue section
Author(s) -
Iwamoto Norihiko,
Nishiyama Etsuko,
Ohwada Jiro,
Noguchi Iwahide,
Kimura Michihiro,
Arai Heii
Publication year - 1995
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1995.tb00283.x
Subject(s) - senile plaques , amyloid (mycology) , chemistry , β amyloid , dementia , formic acid , amyloid β , alzheimer's disease , pathology , biochemistry , medicine , disease
In order to elucidate the enhancement mechanism of amyloid staining by formic acid (FA) pretreatment on a tissue section, we investigated changes of immunoreactivity of amyloid P component (AP) in senile plaques of Alzheimer‐type dementia (ATD) brains. Although immunoreactivity of various amyloidogenic proteins is enhanced by FA treatment, the immunoreactivity of AP was reduced by the treatment in this study. Amyloid P is thought to deposit to amyloid structure by leakage from blood vessels. Therefore, this result suggests that the enhancement effect depends not only on the property of amyloidogenic protein itself but also on the binding form to amyloid structure.