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Coexistence of Creutzfeldt‐Jakob disease and senile dementia of the Alzheimer type
Author(s) -
Wakabayashi Koichi,
Hinokuma Kaoru,
Takahashi Hitoshi,
Seki Koji,
Tanaka Masaharu,
Ikuta Fusahiro
Publication year - 1995
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1995.tb00254.x
Subject(s) - dementia , senile plaques , myoclonus , medicine , alzheimer's disease , astrocytosis , senile dementia , disease , neuroscience , pathology , psychology , psychiatry , central nervous system
An 88 year old woman with slowly progressive dementia of 5 years' duration experienced rapidly progressive consciousness disturbance, myoclonus and periodic synchronous discharge on electro‐encephalography from 3 months before her death. Post‐mortem examination revealed numerous senile plaques reactive with antibody against p‐peptide and widespread occurrence of spongiform change, astrocytosis and marked neuronal loss in the entire cerebral cortex and amygdaloid nucleus. These findings indicate that Creutzfeldt‐Jakob disease (CJD) and senile dementia of the Alzheimer type (SDAT) occurred in the same patient. As the number of aged patients with dementia in care homes and hospitals for the elderly is increasing, it is important to know that CJD can occur late in life during the course of SDAT, as shown in the present case.