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Granulomatous angiitis of the central nervous system
Author(s) -
Hamaya Kazuo,
Nose Soichiro,
Takeshima Masayuki,
Shioji Yasuyuki
Publication year - 1995
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1995.tb00253.x
Subject(s) - langhans giant cell , stupor , medicine , pathology , meningitis , pia mater , autopsy , giant cell , vomiting , cerebral edema , meninges , occipital lobe , surgery , radiology
An 88 year old female had an epileptic attack, followed by fever, vomiting and stupor. A computerized tomogram disclosed bilateral periventricular lucency and a low density area in the right occipital lobe. Antibiotics, hypertonic sodium chloride, steroids, and restricted water intake were ineffective. She died 6 weeks after admission. Autopsy showed that there were extensive irregular necroses in both cerebral hemispheres. Microscopic study disclosed diffuse meningitis and non‐caseating granulomatous inflammation with macrophages and giant cells of Langhans' type in the small‐ and medium‐sized meningeal vessel walls. Some giant cells engulfed elastic membranes in their cytoplasms. The lumina were often thrombosed and her neurological progression was due to diffuse cerebral infarction.