Premium
Pathophysiology of Down Syndrome: Consideration from Clinical Neurology
Author(s) -
Segawa Masaya
Publication year - 1993
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/j.1440-1789.1993.tb00212.x
Subject(s) - pathophysiology , medicine , neurology , neuroscience , serotonergic , lesion , disease , pathology , psychiatry , psychology , serotonin , receptor
Down syndrome (DS) is a representative disorder of mental retardation caused by chromosomal aberration. However, its pathophysiologies have remained unclarified, though its neuropathological similarity to Alzheimer disease is attended. There have been few reports of precise neurological examination of this syndrome for detecting the loci of the lesion. In this report, we present the results of neurlogical and clinical neurophysiological studies on patients with DS and suggest the involvement of serotonergic (5HTergic) neurons as the main pathophysiology of this syndrome.