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Acute liver failure in young children with systemic‐onset juvenile idiopathic arthritis without macrophage activation syndrome: Report of two cases
Author(s) -
Hiejima Eitaro,
Komatsu Haruki,
Takeda Yoshitake,
Sogo Tsuyoshi,
Inui Ayano,
Okafuji Ikuo,
Nishikomori Ryuta,
Nakahata Tatsutoshi,
Fujisawa Tomoo
Publication year - 2012
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2011.02213.x
Subject(s) - medicine , macrophage activation syndrome , arthritis , juvenile , methylprednisolone , complication , liver failure , gastroenterology , juvenile rheumatoid arthritis , immunology , genetics , biology
Acute liver failure (ALF) with macrophage activation syndrome (MAS) is well known as a complication of systemic‐onset juvenile idiopathic arthritis (S‐JIA). However, liver failure without overt MAS is rare in S‐JIA. We encountered two Japanese children with S‐JIA in whom ALF developed during the remission of clinical manifestations. ALF without MAS was improved with plasma exchange and cyclosporine A combined with pulse methylprednisolone.