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Obesity and the developmental origins of health and disease
Author(s) -
Kemp Matthew W,
Kallapur Suhas G,
Jobe Alan H,
Newnham John P
Publication year - 2012
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2010.01940.x
Subject(s) - medicine , disease , organism , observational study , obesity , affect (linguistics) , gerontology , pathology , genetics , biology , communication , psychology
The concept that environmental stimuli imparted on a developing organism have the potential to affect both its short‐ and long‐term developmental profiles is intuitively appealing and, more importantly, supported by a growing body of experimental and observational evidence. A number of groups have posited model hypotheses in tandem with experimental data, linking extrinsic factors to the development of a host of human diseases. Here, we review the evolution of ‘the developmental origins of health and disease’ as a concept and discuss recent advances in the association of specific stimuli to obesity, an epidemic cause of human morbidity and mortality.