Premium
The Australian cerebral palsy research study – Protocol for a national collaborative study investigating genomic and clinical associations with cerebral palsy
Author(s) -
O'Callaghan Michael E,
MacLennan Alastair H,
Gibson Catherine S,
McMichael Gai L,
Haan Eric A,
Broadbent Jessica,
Priest Kevin,
Goldwater Paul N,
Dekker Gustaaf A
Publication year - 2011
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2010.01896.x
Subject(s) - medicine , cerebral palsy , single nucleotide polymorphism , snp , research design , protocol (science) , prospective cohort study , data collection , physical medicine and rehabilitation , genetics , surgery , pathology , statistics , alternative medicine , mathematics , biology , genotype , gene
Aim: Previous studies have proposed a link between the presence of specific single nucleotide polymorphisms (SNPs) and cerebral palsy and the majority of these associations remain to be confirmed or rejected by prospective studies with sufficient statistical power. Prior studies have also given little attention to the interaction of genomic characteristics and clinical risk factors. Methods: This paper describes the design of a prospective case‐control study to test these genetic associations in conjunction with more stringent data collection in respect to clinical features associated with pregnancy, particularly maternal infection. Here we consider the ethical requirements, our hypothesis that genetic susceptibility modifies the risk of cerebral palsy in the presence of perinatal environmental triggers, a priori primary and secondary aims, power calculations, participant recruitment strategies, data linkage, sampling methods of genetic material and subsequent SNP analysis, collection of clinical data and the proposed final statistical analysis.