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Chronic urticaria of neonatal onset: A potential sign of autoinflammation
Author(s) -
Mehr Sam,
Jones Kristi J,
SinghGrewal Davinder,
Aksentijevich Ivona,
Kakakios Alyson
Publication year - 2010
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2009.01688.x
Subject(s) - medicine , inflammation , chronic urticaria , pediatrics , systemic inflammation , immunology
We present a 6 year old boy with chronic urticaria of neonatal onset associated in childhood with features of neurological and joint inflammation. Genetic analysis confirmed the diagnosis of neonatal onset multi‐inflammatory disorder (NOMID). Daily subcutaneous anti‐IL‐1 receptor antagonist therapy resulted in a dramatic and sustained amelioration of systemic inflammation. NOMID must be considered in any child with chronic urticaria of neonatal/infantile onset, particularly if associated with joint and/or neurological inflammation.