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Three siblings with self‐resolving congenital hyperthyrotropinaemia secondary to thyrotropin receptor blocking antibodies
Author(s) -
Azzopardi Peter,
Forrester Mike,
Ehtisham Sarah
Publication year - 2010
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2009.01687.x
Subject(s) - medicine , euthyroid , thyrotropin receptor , endocrinology , thyroid , hormone , antibody , blocking antibody , congenital hypothyroidism , thyrotropin releasing hormone , receptor , thyroid function , graves' disease , immunology
Thyrotropin receptor blocking antibodies are a rare cause of hyperthyrotropinaemia and more rarely of congenital hypothyroidism. We report a case of hyperthyrotropinaemia but normal thyroid hormone in the newborn of a mother with hypothyroidism treated with thyroxine. Two older siblings had similar high thyrotropin and normal thyroid function in the newborn period which did not require hormone treatment and resolved spontaneously. Demonstration of thyrotropin receptor antibodies in the child confirmed our diagnosis. Our case was not treated with thyroid replacement hormone and has remained biochemically euthyroid, with thyrotropin levels returning to normal over a period of months.